DigitalGothik Anti-Virus is about three girls who live in the foggy, older town of "Hawkstead", attending the Catholic boarding school of "St. Christina the Astonishing's School for Girls" (St. Christina's). While in school, the girls barely interact with one another, as they are are apart of separate social cliques. However, after getting into trouble in the computer lab, the three girls are forced to stay after classes to clean up their mess. It is here when their lives are changed forever.